Typically it is possible to at least make some kind of an optimistic case when you bet on football for every team when you think about NFL preseason odds. 
With the Buffalo Bills, that is truly tough to do. They’re given no real chance of winning the AFC East at odds of 30-1 and they’re 125-1 in NFL betting at SBG to win the Super Bowl.
NFL preseason odds could have the Bills as underdogs in all 4 of their preseason games. In their starter at Washington, they will definitely be underdogs. They will likely be underdogs in their 2nd match against Indianapolis which will be played in Toronto. In Week 3 they host the Bengals and they’re likely to be underdogs again although they are at home. Even against the Detroit Lions on the road they are going to be getting points in NFL preseason betting.
The Buffalo Bills have been left out of the playoffs the past decade and they are very likely to miss out once more in 2010. The Bills have lots of issues on both sides of the ball and on the sidelines. Chan Gailey was a short while ago hired by the team as their head coach but he’s not a great NFL head coach. He’ll need to be a great offensive coach with this team, which he can be sometimes. Gailey had previously served as offensive coordinator for the Miami Dolphins, and he has been the head coach of the cowboys. In 1997, when Pittsburgh ranked 6th in the NFL in total offense and 7th in scoring, he was offensive coordinator. Gailey also served as the offensive coordinator for the Kansas City Chiefs in 2008 and three games of the 2009 pre-season. The Chiefs offense was at the bottom of the league in practically every category the season prior to the one when he took over. He was demoted and relieved of duty by the head coach after three pre-season games in 2009. He took the job with the Buffalo Bills in January of this year.
The Bills do not have an amazing starting quarterback, quite little receiving expertise and a doubtful running game. The Bills will attempt to find a starting quarterback between Trent Edwards, Ryan Fitzpatrick and Brian Brohm. Wish them luck. At least the Bills have Fred Jackson who rushed for over a thousand yards last year. In addition they got C.J. Spiller in the first round of the NFL Draft and he should aid. Their only good receiver is Lee Evans. The offensive line is not quite good and no off-season improvements were made.
Linebacker Paul Posluszny, who had over 100 tackles last season, leads their defense, which has only a few gifted participants. Aaron Schobel is seldom motivated to play although he has expertise. The secondary is the one plus side for Buffalo as they have Jairus Byrd who got even for the NFL lead in interceptions with 9. The Bills had the 2nd most interceptions in the league with 28 passes. There are actually a couple more bright spots for Buffalo in NFL preseason odds as kicker Rian Lindell is among the league’s best and punter Brian Moorman is exceptional.
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